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DTSTART;TZID=America/Toronto:20140312T130000
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SUMMARY:Howard Eichenbaum: The Hippocampus in Space and Time
DESCRIPTION:ABSTRACT\n\nIn humans\, hippocampal function is generally recognized as supporting episodic memory\, which is characterized by the organization of experience over time\, whereas in rats\, many believe that the hippocampus creates maps of the environment and supports spatial navigation. How do we reconcile the episodic memory and spatial mapping views of hippocampal function? Here I will discuss evidence that\, during learning of what happens where\, hippocampal place cells map the locations of events in their spatial context. In addition\, I will describe recent findings that\, during learning of what happens when map specific events within their temporal context. These findings support an emerging view that the hippocampus supports episodic memory by creating a “scaffolding” for the organization of events within their spatial and temporal context. \nSPEAKER PROFILE\n\n\nHoward Eichenbaum is a University Professor at Boston University\, where he is also the Director of the Center for Memory and Brain\, Director of the Center for Neuroscience\, and Director of the Undergraduate Program in Neuroscience. Dr. Eichenbaum received his PhD in Psychology from the University of Michigan and also pursued a postdoctoral fellowship in neuroscience at M.I.T. \nRead more about Howard Eichenbaum. \n  \nVIDEO
URL:https://www.rotman.uwo.ca/event/howard-eichenbaum-hippocampus-space-time/
LOCATION:Ontario
CATEGORIES:Philosophy of Mind & Neuroscience
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DTSTART;TZID=America/Toronto:20140321T113000
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CREATED:20170819T173248Z
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SUMMARY:Jonathan Kimmelman: Anatomy of Clinical Translation: Ethics\, Epistemology\, and Policy
DESCRIPTION:ABSTRACT\n\nThe clinical translation process is widely viewed as plagued by inefficiency\, error\, and delay. However\, such views- and the research reforms aimed at correcting these deficiencies- draw on a problematic understanding of the nature of clinical translation (the “pipeline model”). In what follows\, I use the recently translated cancer drug sunitinib to illustrate an alternative model for clinical translation (the “dynamic learning model”). This model is marked by three central features. First\, clinical translation is less about developing drugs than it is about developing intervention ensembles- that is\, packages of materials\, practices\, and knowledge needed to effectuate the clinical utility of new drugs. Second\, clinical translation is marked by clinical research activities that have two distinct epistemic goals: discovery vs. confirmation. Third\, a key task of clinical translation is the refinement of theories that drive clinical decision-making at the bedside. I close by unfolding some of the implications of this model for debates in research ethics\, medical practice\, and drug regulation. \nSPEAKER PROFILE\n\n\nJohnathan Kimmelman is Associate Professor in the Biomedical Ethics Unit / Social Studies of Medicine. He has cross appointments in Experimental Medicine\, Epidemiology\, Biostatistics and Occupational Health\, and Human Genetics. Kimmelman holds a PhD in Molecular Biophysics and Biochemistry from Yale University\, and joined McGill in 2005. His research revolves around the ethical\, social and policy dimensions of translational research. \nRead more about Jonathan Kimmelman.\n \n \nVIDEO
URL:https://www.rotman.uwo.ca/event/jonathan-kimmelman-anatomy-clinical-translation-ethics-epistemology-policy/
LOCATION:Ontario
CATEGORIES:Ethics
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