Joaquin (Quim) Madrenas 2017-09-14T10:18:38+00:00

Project Description

RESEARCH AREAS:

  • Immunology

  • Infectious Diseases

  • Transplantation

CONTACT:

  • Western University
    Robarts Research Institute 2-05
    London, Ontario, Canada N6A 5K8

  • (519) 663-5777 x24242

JOAQUIN (QUIM) MADRENAS

Professor; Department Chair – Microbiology and Immunology
Department of Microbiology and Immunology, McGill University

Dr. Joaquin (Quim) Madrenas is an internationally renowned immunologist and a leader in the field of T cell biology and the development of immunity. He currently holds a Tier I Canada Research Chair in Immunobiology, and is a professor of Microbiology and Immunology, and Medicine at The University of Western Ontario (UWO), and Head of Immunology at Robarts Research Institute. He was the founding Director of the FOCIS Centre for Clinical Immunology and Immunotherapeutics in London, ON. Dr. Madrenas received an M.D. at the University of Barcelona, specialized in Nephrology and Transplantation at the University Autonoma of Barcelona, and obtained a Ph.D. in Immunology under Dr. Phillip Halloran, at the University of Alberta. He was a visiting associate with Dr. Ronald Germain at the National Institutes of Health (Bethesda, MD, USA), before joining Robarts and UWO. He has more than 120 publications and has received many different awards including a Canada Foundation for Innovation Researcher Award, a Premier’s Research Excellence Award, and Ontario Distinguished Researcher Award, The John B. Dossetor Mission Award in Research from The Kidney Foundation of Canada, the UWO Dean’s Award of Excellence in Research and UWO Faculty Scholar Award. In 2011, Dr. Madrenas was elected to the Canadian Academy of Health Sciences.

Dr. Madrenas has made seminal contributions to Science as illustrated by his publications in top journals (Science, Nature Medicine, Immunity, Journal of Experimental Medicine, The Lancet, and the Proceedings of the National Academy of Science USA). Among his discoveries are the different patterns of signalling through the T cell antigen receptor, the mechanisms of signalling by CTLA-4, and the signals delivered to T cells by bacterial superantigens.

As head of Immunology and director of the FOCIS Centre for Clinical Immunology and

Immunotherapeutics, the University of Western Ontario was identified as the most influential Canadian institution in Immunology research during 2000-04 by Thomson Scientific (study on research impact in Education, Medicine, Science, and Technology; http://scientific.thomson.com/products/usi/).

Publications, Articles, and Book Chapters:
Madrenas Puig J, Padro Ubeda L, Codina Puiggros A. Polimiositis y carcinoma pulmonar. Med Clin (Barc) 1984; 82: 514.
Madrenas Puig J, Lu Cortez L, Allende E, Muniz Garcia R, Lience E. Hepatitis toxica por sales de oro. Rev Esp Reumatol 1984; 11: 115.
Miquel Rodriguez F, Cervera Radigales C, de la Calzada Alvarez MD, Sagales Sala MT, Alvarez Sabin J, Matia Guiu Guia J, Madrenas J, Codina Puiggros A. “Alteraciones oculomotoras en las heredoataxias espinocerebelosas.” In: Salisachs P, Berciano J, Codina Puiggros A. Heredodegeneraciones espinocerebelosas (HDEC). Barcelona, Ferrer Internacional, 1984; 143.
Madrenas Puig J, Padro Ubeda L, Codina Puiggros A. “Polimiositis y carcinoma pulmonary”. Med Clin (Barc) 1984; 83: 562.
Fort J, Espinel E, Rodriguez JA, Curull V, Madrenas J, Piera L. “Partial recovey of Renal Function in an Oliguric Patient Affected with Goodpasture’s Syndrome after Treatment with Steroids, Immunosuppressives, and Plasmapheresis.” Clin Nephrol 1984; 22: 211.
Madrenas Puig J, Valles Prats M, Carrera Plans M, Piera Robert L. “Sindrome nefrotica en el secundarisme luetic”. Ann Med (Barc) 1985; 71: 2.
Campins Marti M, Madrenas Puig J, Biosca Gomez de Tejada M, Garcia-Bragado Dalmau F. “Vasculitis leucocitoclastica como manifestacion inicial de una artritis reumatoide”. Med Clin (Barc) 1985; 84: 501.
Biosca M, Garcia-Bragado F, de la Figuera M, Madrenas J, Salas A. “Carcinoid Tumor, Atrophic Gastritis, and Iron-Deficiency Anemia.” Ann Intern Med 1985; 102; 416.
Madrenas Puig J, Lu Cortez L, Astudillo Pombo J. “Enfisema bulloso sobreinfectado: utilidad del drenaje aspirativo intracavitario.” Ann Med Intern 1985; 2: 128.
Madrenas Puig J, de la Figuera M, Biosca M, Saban M, Campins M, Garcia-Bragado F. “Paniculitis lupica”. Rev Esp Reumatol 1985; 12: 51.
Madrenas J, Biosca M, Campins M, Rodrigo MJ, Garcia-Bragado F, Vilardell M. “Gammapathie Monoclonale et Proteinurie de Bence-Jones Transitoires au cours d’une Pneumonie”. Presse Med 1985; 14: 1562.
Madrenas J, Curull V, Barbero L, Vidal R, Morell F. “Non Immunological Analytic Data for the Differential Diagnosis between Miliary Tuberculosis (MTBC) and Bird Breeder’s Disease (BBD)”. Allergol Immunopathol 1985; 13: 301.
Madrenas J, Codina S, Fort J, Rodriguez JA, Ferrer E, Piera L. “Glomerulonefritis por anticuerpos anti-membrana basal y sindrome de Goodpasture: presentacion clinica y tratamiento”. Rev Soc Esp Dial Transplan 1985; 7: 117.
Madrenas Puig J, Tovar Mendez JL. “El sistema renina-angiotensina-aldosterona: aspectes fisiologics”. Ann Med (Barc) 1985; 71: 257.
Madrenas Puig J, Pigrau Serrallach C, Martinez Vazquez JM. “El metabolismo del magnesio y sus transtornos”. Med Clin (Barc) 1986; 87: 159.
Madrenas J, Mayol A, Carreras L, Codina S, Camps J, Capdevila L, Rodriguez JA. “Complicaciones infecciosas en los pacientes sometidos a hemodialisis periodicas”. Rev Soc Esp Dial Transplan 1986; 8: 21.
Madrenas J, Valles M, Ferrer E, Piera L. “Aparicion de una vasculitis tipo poliarteritis nudosa en un paciente en programa de hemodialisis portador de HBsAg”. Med Clin (Barc) 1986; 86: 825.
Madrenas J, Codina S, Monne J, Garcia-Lucena MV, Rodriguez JA, Ferrer E, Piera L. “Digoxin-Like Immunoreacting Activity in the Serum of Patients on Regular Hemodialysis”. Nephron 1986; 43: 303.
Campins M, Madrenas J, Biosca M, Salas A, Tallada N, Garcia-Bragado F. “Extra-Uterine Mullerian Carcinosarcoma”. Acta Obstet Gynecol Scand 1986; 65: 811.
Monforte F (+), Madrenas J, Tovar JL, Idoipe JL. “Desaparicion de la hipertension arterial (HTA) tras nefrectomia en el infarto renal por trombosis de la vena renal (TVR)”. Med Clin (Barc) 1986; 87: 391.
Madrenas J, Galicia MA, Valles M, Ferrer E, Piera L. “Glomerulonefritis y hemorragia pulmonary”. Med Clin (Barc) 1987; 88: 97.
Valles M, Galicia MA, Madrenas J, Carrera M, Morlans M, Fort J, Ferrer E, Piera L. “Vasculitis sistemica con afectacion predominantemente renal”. Med Clin (Barc) 1987; 88: 356.
Madrenas J, Garcia-Bragado F, Fernandez JM. “Anterior tibial compartment syndrome secondary to systemic capillary leak syndrome.” J Neurol Neurosurg Psychiatry 1987; 50: 943.
Valles M, Madrenas J, Barquinero J. “Seudohipoaldosteronismo transitorio secundario a uropatía obstructive”. Med Clin (Barc) 1987; 88: 740.
Madrenas J, Newman S, McGregor JR, Kovithavongs T, Lakey WH, Dossetor JB. “The Effect of Cyclosporine on One-Centre Long-Term Multivariate Analysis of Kidney Transplants.” Transplant Proc 1988; 20 (Suppl. 3): 86.
Madrenas J, Newman S, McGregor JR, Kovithavongs T, Lakey WH, Dossetor JB, Halloran PF. “An Alternative Approach for Statistical Analysis of Kidney Transplant Data: Multivariate Analysis of Single-Centre Experience”. Am J Kidney Dis 1988; 12: 524.
Halloran PF, Cockfield SM, Madrenas J. “The Molecular Immunology of Transplantation and Graft Rejection”. Immunology and Allergy Clinics of North America 1989; 9: 1.
Halloran PF, Cockfield SM, Madrenas J. “The Mediators of Inflammation (Interleukin-1, Interferon-g, and Tumor Necrosis Factor) and Their Relevance to Rejection”. Transplant Proc 1989; 21: 26.
Halloran PF, Madrenas J. “The Induction of the Immune Response. In: First Canadian Symposium on Multi-Organ Transplantation”. Ortho Pharmaceutical (Canada) Ltd., and University Hospital Foundation, London, Canada. 1989: 3.
Madrenas J, Vallés M, Ruiz Marcellan MC, Fort J, García Bragado F, Pelegrí A. “Hemorragia pulmonar y glomerulonefritis asociados a crioglogulinemia mixta esencial”. Med Clin (Barc) 1989; 93: 262-264.
Halloran PF, Madrenas J. “Regulation of MHC Transcription”. Transplantation 1990; 50: 725.
Halloran PF, Madrenas J. “The Mechanism of Action of Cyclosporine: A Perspective for the 90′s”. Clin Biochem 1991; 24: 3.
Madrenas J, Pazderka F, Baergen C, Halloran PF. “Isolation of a Murine Renal Cell Population which Expresses a Truncated T Cell Receptor a mRNA”. Transplant Proc 1991; 23: 837.
Madrenas J, Parfrey NA, Halloran PF. “Interferon-Gamma Mediated Renal MHC Expression in Mercuric Chloride-Induced Glomerulonephritis”. Kidney Int 1991; 39: 273.
Madrenas J, Pazderka F, Parfrey NA, Halloran PF. “Thymus-Independent Expression of a Truncated T Cell Receptor a mRNA in Murine Kidney”. J Immunol 1992; 148: 612.
Gill N, Madrenas J, Halloran PF. “Complement-Dependent Cytotoxicity for Negative Selection at the mRNA Level”. Immunol Invest 1992; 21: 629.
Kjellstrand CM, Madrenas J, Solez K. “Pronóstico y tratamiento de la insuficiencia renal aguda”. Nefrología 1992; XII (Supl. 4): 249.
Halloran PF, Broski AP, Batiuk TD, Madrenas J. “The Molecular Immunology of Acute Rejection: An Overview”. Transplant Immunol 1993; 1: 3.
Blake PG, Madrenas J, Halloran PF. “Ly-6 in Kidney is Widely Expressed on Tubular Epithelium and Vascular Endothelium and is Up-Regulated by Interferon Gamma”. J Am Soc Nephrol 1993; 4: 1140.
Madrenas J, Vincent DH, Kriangkum J, Elliott JF, Halloran PF. “Alternatively Spliced, Germline Ja11-2 – Ca mRNAs are the Predominant T Cell Receptor a Transcripts in Mouse Kidney”. Mol Immunol 1994; 31: 993.
Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. z “Phosphorylation Without ZAP-70 Activation Induced By T Cell Receptor Antagonists or Partial Agonists”. Science 1995; 267: 515.
Germain RN, Levine EH, Madrenas J. “The T Cell Receptor as a Diverse Signal Transduction Machine”. The Immunologist 1995; 3: 113.
Madrenas J. Tirosina. Multifacética Fosforilación. Investigación y Ciencia (Spanish Edition of Scientific American) 1995; September issue: 34.
Madrenas J, Germain RN. Variant TCR Ligands: “New Insights into the Molecular Basis of Antigen-Dependent Signal Transduction and T Cell Activation”. Semin Immunol 1996; 8: 83.
Madrenas J, Schwartz RH, Germain RN. “Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists”. Proc Natl Acad Sci USA 1996; 93: 9736.
Gao JX, Madrenas J (corresponding author), Zeng W, Zhong R, Grant D. “Generation of dendritic cell-like antigen-presenting cells in long-term mixed leucocyte culture: phenotypic and functional studies”. Immunology 1997; 91: 135.
Madrenas J, Chau L, Smith J, Bluestone JA, Germain RN. “The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide-MHC Molecule Ligands”. J Exp Med 1997; 185: 219.
Lee JE, Cossoy MB, Chau LA, Singh B, Madrenas J. Lck “Inactivation and Loss of TCR-mediated Signalling upon Persistent Engagement with Complexes of Peptide:MHC Molecules”. J Immunol 1997; 159: 61.
Madrenas J, Lazarovits AI. “Differential Signaling through the T cell Receptor: from Biochemistry to Transplantation Tolerance”. Histol Histopathol 1998; 13: 221.
Salojin K, Zhang J, Madrenas J, Delovitch TD. “T cell anergy: biochemical basis and possible relationship to the development of autoimmune disease”. Immunol Today 1998; 19: 468.
Nabavieh A, Chou H, Volokhov I, Lee JE, Purdy LE, Elliott JF, Singh B, Madrenas J. “Development of an I-Ag7-expressing antigen presenting cell line: intrinsic molecular defect in compact I-Ag7 dimer generation”. J Autoimmunity 1998; 11: 63.
Chau LA, Bluestone JA, Madrenas J. “Dissociation of intracellular signalling pathways in response to partial agonist ligands of the T cell receptor”. J Exp Med 1998; 187: 1699.
Jiang J, Wang H, Madrenas J, Zhong R. “Surgical technique for vascularized thymus transplantation in mice”. Microsurgery 1999; 19: 56.
Baroja ML, Cielinski LB, Torphy TJ, Wange RL, Madrenas J. “Specific CD3-e association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation”. J Immunol 1999; 162: 2016.
Khandaker MH, Mitchell G, Rahimpour R, Xu L, Andrews JD, Singh R, Leung H, Madrenas J, Ferguson SGS, Feldman RD, Kelvin DJ. “Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-a mediated regulation of CXCR1 and CXCR2 chemokine receptor expression”. Blood 1999; 93: 2173.
Mitchell GB, Khandaker M, Rahimpour R, Xu L, Lazarovits AL, Pickering JG, Suria H, Madrenas J, Pomerntz DK, Feldman RD, Kelvin DJ. “CD45 modulation of CXCR1 and CXCR2 in human polymorphonuclear leukocytes”. Eur J Immunol 1999; 29: 1467.
Chau LA, Madrenas J. “Phospho-LAT-independent activation of the ras-MAPK pathway: a differential recruitment model of TCR partial agonist signaling”. J Immunol 1999; 163: 1853.
Hess DA, Sisson ME, Suria H, WisjmanJ, Puvanesasingham R, Madrenas J, Rieder MJ. “Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8+ cells by hydroxylamine of sulfametoxazole”. FASEB J 1999; 13: 1688.
Gao JX, Madrenas J (corresponding author), Zeng W, Zhong R, Wang JJ, Grant D. “Dendritic cells producing IL-10, but not IL-12 induce polyclonal T cell hyporesponsiveness in vitro and prevent acute allograft rejection”. Immunology 1999; 98: 159.
Suria H, Chau LA, Negrou E, Kelvin DJ, Madrenas J. “Cytoskeletal disruption induces T cell apoptosis by a caspase 3-mediated mechanism”. Life Sciences 1999; 65: 2697.
Madrenas J. “Differential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation”. Life Sciences 1999; 64: 717.
Madrenas J. “Lymphocytes: antigen-induced gene activation”. In Encyclopedia of Life Sciences November 1999; Nature Publishing Group, London, www.els.net.
Madrenas J. “Triggering of the T cell receptor: Implications for Transplantation”. Graft 2000; 3 (supp. 1): S3.
Baroja ML, Darlington PJ, Carreno BM, Madrenas J. “Inhibition of T Cell Activation by CTLA-4: Truths and Red Herrings”. Modern Aspects of Immunobiology 2000; 1: 169.Madrenas J. “Historia d’un descobriment: Reflexions del passat, prediccions pel futur”. Annals de Medicina 2000; 83: 286.
Xu L, Khandaker M, Barlic J, Ran L, Baroja ML, Madrenas J, Rahimpour R, Chen K, Mitchell G, Tan CM, De Vries M, Feldman RD, Kelvin DJ. “Identification of a novel mechanism for endotoxin-mediated down-modulation of CC chemokine receptor expression”. Eur J Immunol 2000; 30: 227.
Baroja ML, Luxenberg D, Chau T, Ling V, Strathdee CA, Carreno BM, Madrenas J. “The inhibitory function of CTLA-4 is independent of its tyrosine phosphorylation”. J Immunol 2000; 164: 49.
Abu-hadid MM, Lazarovits AI, Madrenas J. “Prevention of diabetes mellitus in the Non-Obese Diabetic mouse strain with monoclonal antibodies against the CD45RB molecule”. Autoimmunity 2000; 32: 73.
Carreno BM, Bennett F, Chau TA, Ling V, Luxenberg D, Jussif J, Baroja ML, Madrenas J. “CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression”. J Immunol 2000; 165: 1352.
Tomas EM, Darlington PJ, Chau LA, Madrenas J. “The Role of Ezrin in T Cell Receptor (TCR)-Dependent Signalling”. Transplant Proc 2001; 33: 207.
Chau LA, Tso JY, Madrenas J. “Generation of partial agonist ligands of the T cell receptor by engineering of antibodies against CD3″. Transplant Proc 2001; 33: 528.
Chau LA, Tso JY, Melrose J, Madrenas J.HuM291 (Nuvion™), A Humanized Fc Receptor-Nonbinding Antibody against CD3, Anergizes Peripheral Blood T Cells as Partial Agonist of the T Cell Receptor”. Transplantation; 2001; 71: 941.
Hess DA, O’Leary EF, Lee JF, Almawi WY, Madrenas J, Rieder MJ. “Inhibition of cytokine production and interference in IL-2 receptor mediated Jak-Stat signaling by the hydroxylamine metabolite of sulfamethoxazole”. FASEB J 2001; 15: 1855.
Shan X, Balakir R, Criado G, Wood JS, Seminario MC, Madrenas J, Wange RL. “ZAP-70-independent Ca2+ Mobilization and Erk Activation in Jurkat T cells in Response to T Cell Antigen Receptor Ligation”. Mol Cell Biol 2001; 21: 7137.
Chau LA, Rohekar S, Wang, JJ,Lian D, Chakrabarti S, Zhang L, Zhong R, Madrenas J. “Thymic Re-Entry of Mature Activated T cells and Increased Negative Selection in Vascularized Allograft Recipients”. Clin Exp Immunol 2002; 127: 43.
Gardiner GE, Heinemann C, Baroja ML, Bruce AW, Beuerman D, Madrenas J, Reid G. “Oral administration of the probiotic combination Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 for human intestinal applications”. International Dairy J 2002; 12:191.
Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J (shared senior corresponding authorship), Kuchroo VK. “Inhibition of CTLA-4 function by the Regulatory Subunit of PP2A”. J Immunol 2002; 168: 5070.
Darlington PJ, Baroja ML, Chau TA, Siu E, Ling V, Carreno BM, Madrenas J. “Surface CTLA-4 Partitions Within Lipid Rafts and Relocates to the Immunological Synapse in Conditions of T Cell Inactivation”. J Exp Med 2002; 195: 1337.
Tomas EM, Chau TA, Madrenas J. “Clustering of lipid rafts-associated pool of ERM proteins at the immunological synapse upon T cell receptor or CD28 ligation”. Immunol Lett 2002; 83: 143.Madrenas J. “Interview about CTLA-4″. Modern Aspects of Immunobiology 2002; 2: 244.
Madrenas J. “A SLAT in the Th2 signalosome”. Immunity 2003; 18: 459.
Baroja ML, Madrenas J. “Viewpoint: Therapeutic implications of CTLA-4 compartmentalization”. Am J Transplant 2003; 3: 919.
DeVries ME, Cao H, Wang J, Xu L, Kelvin AA, Ran L, Chau LA, Madrenas J, Hegele RA, Kelvin DJ. “Genomic Organization and Evolution of the CX3CR1/CCR8 Locus”. J Biol Chem 2003; 278: 11985.
Puig-Kröger A, Muñiz-Pello O, Selgas R, Criado G, Bajo MA, Sánchez-Tomero JA, Alvarez V, del Peso V, Sánchez-Mateos P, Holmes C, Faic D, López-Cabrera M, Madrenas J, Corbí AL. “Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: Effect of Lactate and Glucose-degradation products”. J Leukocyte Biol 2003; 73: 482.
Arp J, Kirchhof MG, Baroja ML, Nazarian SH, Chau TA, Strathdee CA, Ball EH, Madrenas J. “Regulation of T cell activation by phosphodiesterase 4B2 requires its dynamic redistribution during synapse formation”. Mol Cell Biol 2003; 23: 8042.
Siu E, Carreno BM, Madrenas J. “T Cell Receptor Subunit Specificity of CTLA-4-mediated Signalling” J Leukocyte Biol 2003; 74: 1102.
Criado G, Madrenas J. “Superantigen Stimulation Reveals the Contribution of Lck to Negative Regulation of T Cell Activation”. J Immunol 2004; 172: 222.Yu XZ, Levin SD, Madrenas J, Anasetti C. “Lck is required for activation-induced T-cell death after TCR ligation with partial agonists”. J Immunol 2004; 172: 1437.
Madrenas J, Chau L A, Teft W A, Wu P W, Jussif J, Kasaian M, Carreno B M, Ling V. “Conversion of CTLA-4 from Inhibitor to Activator of T Cells with a Bispecific Tandem Single-Chain Fv Ligand”. J Immunol 2004; 172: 5948.
Giguère J-F, Bounou S, Paquette J-P, Madrenas J, Tremblay MJ. “Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle”. J Virol 2004; 78: 6222.
Li L, Baroja ML, Majumdar A, Chadwick K, Rouleau A, Gallacher L, Ferber I, Lebkowski J, Martin T, Madrenas J, Bhatia M. “Human Embryonic Stem Cells Possess Immune-Privileged Properties”. Stem Cells 2004; 22: 448.Bueno C, Chau LA, Lee-Chan E, Singh B, Strejan GH, Madrenas J. “Mechanism of modulation of T cell responses by N-palmitoylated peptides”. Eur J Immunol 2004; 34: 3497.
Criado G, Madrenas J. “Lymphocytes: antigen-induced gene activation”. In Encyclopedia of Life Sciences August 2004, 2nd. edition; Nature Publishing Group, London, www.els.net.
Barquinero J, Madrenas J, Salgado A, Vidal J, Vilardell M. “Diccionario de Medicina Molecular, Novartis ediciones”, 2005.
Leon-Ponte M, Kirchhof MG, Sun T, Stephens T, Singh B, Sandhu S, Madrenas J. “Polycationic Lipids Inhibit the Pro-Inflammatory Response to LPS”. Immunol Lett 2005; 96: 73.
McCully ML, Chau TA, Luke P, Blake PG, Madrenas J.Characterization Of Human Peritoneal Dendritic Cell Precursors and Their Involvement in Peritonitis”. Clin Exp Immunol 2005; 139: 513.
Darlington PJ, Kirchhof MG, Criado G, Sondhi J, Madrenas J. “Hierarchical Regulation Of CTLA-4 Dimer-Based Lattice Formation And Its Biological Relevance For T-Cell Inactivation”. J Immunol 2005; 175: 996.Giguère J-F, Diou J, Madrenas J, Tremblay MJ. “Virus attachment and replication are promoted upon acquisition of host CD28 and CD152 by human immunodeficiency virus 1″. J Infect Dis 2005; 192: 1265.
Madrenas J, Potter P, Cairns E. “Giving credit where credit is due: John Hunter and the discovery of erythrocyte sedimentation rate”. The Lancet 2005; 366: 2140.
Jimenez-Perianez A, Ojeda G, Criado G, Sanchez A, Pini E, Madrenas J, Rojo JM, Portolés P. “Complement Regulatory Protein Crry/p65-Mediated Signalling in T Lymphocytes: Role Of Its Cytoplasmic Domain and Partitioning into Lipid Rafts”. J Leukocyte Biol 2005; 78: 1386.
Chen G, Sun H, Arp J, Garcia B, Wang X, Wise Y, Liu W, Ramcharran S, Huang X, Xiang Y, Yang H, Fang Z, Madrenas J, Sudo Y, Tamura K, Zhong R. “A Synergistic Effect Between PG490-88 and Tacrolimus Prolongs Renal Allograft Survival in Monkeys”. Am J Transplant 2006; 6: 714.
Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SSG, Rahman AKMN, Tsoukas CD, McCormick JK, Madrenas J. “Bacterial Superantigens Bypass Lck-Dependent TCR Signalling by Activating a Ga11-dependent, PLC-b-mediated Pathway”. Immunity 2006; 25: 67. (Twice highlighted in Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1033930/evaluation; editorial in Science STKE).
Thomson CW, Teft WA, Chen W, Madrenas J, Zhang L. “FcRg presence in TCR complex of double negative T cells is critical for their regulatory function”. J Immunol 2006; 177: 2250.
Zhang Z, Ma Y, Wang H, Arp J, Jiang J, Huang X, He KM, Garcia B, Madrenas J, Zhong R. “Double negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzyme-dependent, Fas-FasL-independent pathway”. J Immunol 2006; 177: 6920.
Rahman KMN, Herfst CA, Moza B, Shames SR, Chau LA, Bueno C, Madrenas J, Sandberg EJ, McCormick JK. “Molecular Basis of TCR Selectivity, Cross-Reactivity and Allelic Discrimination by a Bacterial Superantigen: Integrative Functional and Energetic Mapping of the SpeC-Vb2.1 Molecular Interface”. J Immunol 2006; 177: 8595.
Small TW, Bolender Z, Bueno C, O’Neil C, Nong Z, Rushlow W, Rajakumar N, Kandel C, Strong J, Madrenas J, Pickering JG. “Wilms’ Tumor 1-Associating Protein Regulates the Proliferation of Vascular Smooth Muscle Cells”. Circ Res; 2006; 99: 1338.McCully ML, Madrenas J. “Dendritic cells as arbiters of peritoneal immune responses”. Perit Dial Int 2006; 26: 8.
Teft WA, Kirchhof MG, Madrenas J. “A molecular perspective of CTLA-4 function”. Annu Rev Immunol 2006; 24: 65.
Kirchhof MG, Madrenas J. “Membrane compartmentalization during T cell receptor signalling and immunological synapse formation”. Inmunologia 2006; 25: 131.
Teft WA, Madrenas J. “The immunological synapse as a novel therapeutic target”. Curr Opin Investig Drugs. 2006; 7: 1008.
Bueno C, Criado G, McCormick JK, Madrenas J. “T cell signalling induced by bacterial superantigens. In Marone G (editor): Superantigens and Superallergens”. Chem Immunol Allergy. 2007; 93:161.
Brouillard JNP, Günther S, Varma AK, Gryski I, Herfst CA, Rahman AKMN, Leung DYM, Schlievert PM, Madrenas J, Sundberg EJ, McCormick JK. “Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by Group V superantigens”. J Mol Biol 2007; 367: 925.
McCully ML, Baroja ML, Chau TA, Jain AK, Barra L, Salgado A, Blake PG, Madrenas J. “Up-regulation of receptor interacting protein 2 correlates with rapid resolution of peritoneal dialysis-associated peritonitis”. Kidney Int 2007; 72: 1273.
Teft WA, Madrenas J. “Molecular determinants of inverse agonists activity of biologicals targeting CTLA-4″. J Immunol 2007; 179: 3631.
Fairhead T, Lian D, McCully ML, Garcia B, Zhong R, Madrenas J. “RIP2 is required for NOD signaling but not for Th1 cell differentiation and cellular allograft rejection”. Am J Transplant 2008; 8: 1143.
McCully ML, Fairhead T, Colmont CS, Besley FC, Heinrichs DE, Blake PG, Topley N, Madrenas J. “RIP2 deficiency delays macrophage migration and increases intracellular infection during PD-associated peritonitis”. Am J Nephrol 2008; 28: 879.McCully ML, Fairhead T, Blake PG, Madrenas J. “The future of receptor-interacting protein 2 (RIP2) as a biomarker of the inflammatory response to infection”. Expert Rev Mol Diagn 2008; 8: 257.
García-Castro J, Trigueros C, Madrenas J, Pérez-Simón JA, Rodriguez R, Menendez P. “Mesenchymal Stem Cells and their use as cell replacement therapy and disease modeling tool”. J Cell Mol Med 2008; 12: 2552.
Kirchhof MG, Chau LA, Lemke CD, Vardhana S, Darlington PJ, Márquez ME,Taylor R,Rizkalla K, Blanca I,Dustin ML,Madrenas J. “Modulation of T cell activation by stomatin-like protein 2″. J Immunol 2008; 181: 1927.
Teft WA, Madrenas J. “Characterization of Oligomers induced by Inverse agonists of CTLA-4″. Immunol Lett 2008; 120: 29.
Kasper KJ, Xi W, Rahman AKMN, Kotb M, Sundberg EJ, Madrenas J , McCormick JK. “Molecular Requirements for MHC Class II a-Chain Engagement and Allelic Discrimination by the Bacterial Superantigen SpeC”. J Immunol 2008; 181: 3384.
Stephens,TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S, Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SMM, Madrenas J, Singh B. “Dendritic Cell Differentiation Induced By A Self-Peptide Derived From Apolipoprotein E.” J Immunol 2008; 181: 6859.
Teft WA, Chau TA, Madrenas J. “Structure-Function analysis of the CTLA-4 interaction with PP2A”. BMC Immunol 2009; 10: 23.
Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Vinés ED, Kubes P, Haeryfar SMM, McCormick JK, Cairns E, Heinrichs DE, Madrenas J. “TLR2 Ligands on the Staphylococcal Cell Wall Down-regulate Superantigen-Induced T Cell Activation and Prevent Toxic Shock Syndrome”. Nature Medicine 2009; 15: 641. (Highlighted as Exceptional Paper in Faculty of 1000 Medicine: http://www.f1000medicine.com/article/id/1161383/evaluation. Also, paper featured in The Economist June 13/2009 issue, p.84).
Hayworth J L, Kasper KJ, Leon-Ponte M, Herfst CA, Yue D, Brintnell WC, Mazzuca DM, Heinrichs DE, Cairns E, Madrenas J, Hoskin DW, McCormick JK, Haeryfar SMM. “Attenuation of Massive Cytokine Response to the Staphylococcal Enterotoxin B Superantigen by the Innate Immunomodulatory Protein Lactoferrin”. Clin Exp Immunol 2009; 157: 60.
Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CS, Xenocostas A, Kipps TJ, Hennighausen T, Iwama A, Nakauchi H, Kawakami T. “Tumor suppression by phospholipase C-b3 via SHP-1-mediated dephosphorylation of Stat5″. Cancer Cell 2009; 16: 161.
Spence JD, Li H, Tamayo A, Munoz C, Hackam DG, DiCicco M, DesRoches J, Coates V, Bogiatzi C, Klein J, Madrenas J, Hegele RA. “Intensive Medical Therapy Reduces Microemboli and Cardiovascular Risk in Asymptomatic Carotid Stenosis”. Arch Neurol 2010; 67: 180.Yue D, Brintnell W, Mannik LA, Christie DA, Haeryfar SMM, Madrenas J, Chakrabarti S,4 Bell DA, Cairns E. “CTLA4-Ig blocks the development and progression of citrullinated human fibrinogen-induced arthritis in DR4 tg mice”. Arthritis Rheum 2010;62: 2941.
Mele T, Madrenas J. “TLR2 signalling: At the Crossroads of Commensalism, Invasive Infections and Toxic Shock Syndrome by Staphylococcus aureus”. Int J Biochem Cell Biol 2010; 42: 1066.
Toth JM, Hewson GL, Frodermann V, Chau LA, Azike C, Lui E, Madrenas J. “Modulatory Effects of Ginseng Extracts on Human Innate and Adaptive Immune Responses”. In: Advances in Ginseng Research. Proceedings of the 10th International Symposium on Ginseng. Yang DC, Kim SK, Oh HI, Eds. The Korea Ginseng Society Press, 2010, pp.: 383-394.
Rahman AKMN, Bonsor DA, Herfst CA, Pollard F, Peirce M, Wyatt AW, Kasper KJ, Madrenas J, Sundberg EJ, Mccormick JK. “The T Cell Receptor b-Chain Second Complementarity Determining Region Loop (CDR2β) Governs T Cell Activation and Vβ-Specificity by Bacterial Superantigens”. J Biol Chem 2011; 286: 4871.
Filler G, Liu D, Huang SS, Casier S, Chau LA, Madrenas J. “Impaired GFR is the most important determinant for FGF-23 increase in chronic kidney disease”. Clin Biochem 2011; 44: 435.
Frodermann V, Chau TA, Sayedyahossein S, Toth JM, Heinrichs DE, Madrenas J. “A Modulatory IL-10 Response to Staphylococcal Peptidoglycan Prevents Th1 / Th17 Adaptive Immunity to S. aureus”. J Infect Dis 2011; in press.
El-Far M, Isabelle C, Chomont N, Bourbonnière M, Fonseca S, Ancuta P, Said EA, Peretz Y, Chouikh Y, Eichbaum Q, van Grevenynghe J, Halwani R, Schwartz O, Madrenas J, Freeman GJ, Boulassel MR, Routy JP, Haddad EK, Sékaly RP. “HIV-1 Nef enhances T cell activation and viral replication by facilitating CTLA-4 accelerated degradation”. J Virol 2011; manuscript accepted pending revisions.
Christie DA, Lemke CD, Elias IM, Chau LA, Kirchhof MG, Li B, Ball EH, Dunn SD, Hatch GM, Madrenas J. “Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function”. Manuscript submitted
Review duties for Professional Journals:
Nature Medicine
Immunity, Cambridge, MA.
The Journal of Experimental Medicine, New York, NY
Proceedings of the National Academy of Sciences USA (PNAS)
The Journal of Immunology, Bethesda, MD Associate Editor 2006-2010
The Journal of Clinical Investigation
Blood
Diabetes
The Journal of Biological Chemistry, Bethesda, MD
Pharmacological Reviews Associate Editor 2007-2010
JASN (Journal of the American Society of Nephrology)
The Journal of Leukocyte Biology, Frederick, MD
European Journal of Immunology, Freiburg, Germany
Cellular Immunology, San Diego, CA.
Oncogene
Cell Death & Differentiation
International Immunology
The Journal of Gerontology – Biological Sciences, La Jolla, CA.
American Journal of Transplantation Associate Editor 2008-2011
American Society of Transplantation, Mt. Laurel, NJ
Nephrology, Dialysis, and Transplantation
Peritoneal Dialysis International
Experimental and Therapeutic Medicine Editorial Board 2009-present
Journal of Neuroimmunology
Inmunologia Editorial Board 2006-present
Journal of Zhejiang University Science
Invited Talks and Conference Presentations:

Madrenas J, Galicia M. Insuficiencia Renal Funcional y Hepatopatia Cronica. Jornada de Actualizacion en Nefrologia. Hospital de Girona ‘Alvarez de Castro’, Girona (Spain), Feb. 14, 1986.
Madrenas J, Galicia M. Insuficiencia Renal Funcional i Hepatopatia Cronica. 1r. Jornades d’Actualitzacio en Nefrologia. Barcelona (Spain), Mar. 13, 1986.
Valles M, Tovar JL, Madrenas J. Valor Actual de les Tecniquès Diagnostiques en Nefrologia. X Curs d’Ensenyament Continuat de Medicina Interna per a Postgraduats. Barcelona (Spain), Course 1986.
Madrenas J. Unexpected Expression of a Truncated T Cell Receptor a mRNA in Mouse Kidney. Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD, USA. April 13, 1992.
Madrenas J. Expression of Non-Rearranged T Cell Receptor alpha-Chain in Non-Lymphoid Cells of the Mouse Kidney. La Jolla Institute of Immunology and Allergy. La Jolla, CA, USA. April 27, 1992.
Madrenas J. Antagonistes del Limfocit T: Una Alternativa en el Control de la Immunitat Cel.lular. Ciutat Sanitaria ‘Vall d’Hebrón’, Barcelona, Spain, December 16, 1993.
Madrenas J. Mechanism of Action of TCR Antagonists: Bits of Data, Lots of Models. laboratory of Immunology – Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, U.S.A. January 13, 1994.
Madrenas J. Mechanism of Action of TCR Antagonists. RRI Seminar Series, Transplant Immunobiology Group. The John P. Robarts Research Institute, University of Western Ontario, London, Ontario, Canada, October 3, 1994.
Madrenas J. Guest Researcher, Celebration of Medical Research Night, London, Ontario, Canada. Nov. 2, 1995.
Madrenas J. Seeing Quality: Lessons from T Cell Receptor-Mediated Signalling. The University of Western Ontario Signal Transduction Group, London, Ontario, Canada. Nov. 3, 1995.
Madrenas J. Dissecting T Cell Activation. Department of Microbiology and Immunology Guest Seminar. The University of Western Ontario, London, Ontario, Canada. Nov. 23, 1995.
Madrenas J. New developments in T cell activation. University Hospital Foundation, the University of Western Ontario, February 27, 1996, London, Ontario, Canada.
Madrenas J. The Immune System: from Taxes to Plagues, from Mice to Molecules. On the Road to Discovery Lecture Series. The John P. Robarts Research Institute, May 8, 1996, London, Ontario, Canada.
Madrenas J. Lack of Co-engagement of T Cell Receptor and CD4 Determines Partial Agonist T Cell Responses: from Biochemistry to Transplantation. Multi-Organ Transplant Program Research Forum, October 30, 1996, London, Ontario, Canada.
Madrenas J. Serine phosphorylation of lck causes T cell receptor desensitization. Atherosclerosis/Signal transduction group. The University of Western Ontario, February 12, 1997, London, Ontario, Canada.
Madrenas J. Long-term transplant survival: from biochemical changes to the induction of transplantation tolerance. Annual Southwestern Ontario Nephrology Group Meeting, June 10, 1997, London, Ontario, Canada.
Madrenas J. Altered peptide ligands and T cell receptor signaling. Basic Science Symposium on Evolving Concepts in Immune Regulation. Canadian Transplantation Society Annual Meeting, Vancouver, B.C., Canada. Sept. 26, 1997.
Madrenas J. Regulatory checkpoints in T cell receptor-mediated signalling. Genetics Institute Inc. Seminar Series. Boston, MA, November 18-19, 1997.
Madrenas J. Dissociation of intracellular signalling pathways after TCR engagement with partial agonist ligands. Immunology Network Seminar Series, University of Alberta. Edmonton, AB, March 10, 1998.
Madrenas J. The T-cell receptor as a versatile signal transduction complex. Medical Research Council Transplantation Group Series, University of Toronto. Toronto, ON, May 14, 1998.
Madrenas J. Current research and future developments in xenotransplantation. The X-files: Issues in Xenotransplantation. The Kidney Foundation of Canada Leadership Conference and Annual General Meeting, St. John’s, NF, June 12-14, 1998.
Madrenas J. Xenotransplantation: Strategies for Addressing Organ Transplant Shortage. B.C. Nephrology Day. Vancouver, B.C., October 22-23, 1998.
Madrenas J. The plasticity of T-cell receptor-mediated signal transduction. London Regional Cancer Centre Experimental Oncology Seminar Series, November 26, 1998.
Madrenas J. Off, on, and in between: Differential Signalling from the T cell Receptor for Antigen. McGill Cancer Centre Seminar Series, Montreal, PQ, December 19, 1998.
Madrenas J. Signal specificity from the T cell receptor: off, on, and in between. Department of Pathology Seminar Series and Graduate Course in Pathology, University of Rochester, Rochester, NY, January 20, 1999.
Madrenas J. Signal transduction by the antigen receptor of T lymphocytes: from biochemistry to transplantation tolerance. Nephrology course, Institute of Nephrology, La Havana, Cuba, Feb 25, 1999.
Madrenas J. Specificity of sigal transduction by the T cell receptor. Centro de Inmunología Molecular, La Havana, Cuba, Feb 25, 1999.
Madrenas J. Activació de Linfòcits T: Ni tot ni res, solament el necessari. Centre d’Investigacions en Bioquímica I Biología Molecular, Hospitals ‘Vall d’Hebron’. Barcelona, Spain. Apr. 13, 1999.
Madrenas J. Regulation of signal specificity from the T cell receptor for antigen. Gerontology Research Center, National Institute of Aging, NIH, Baltimore, MD, Apr. 22, 1999.
Madrenas J. Mechanisms of signal specificity used by the T cell receptor. Medical Research Council Transplantation Group Seminar Series, University of Toronto. Toronto, ON, May 11, 1999.
Madrenas J. Retos para el principio del milenio: el donde, el como, y el cuando de la transduccion de senales en linfocitos. Club de Inmunologia Experimental, Caracas, Venezuela. Nov. 23, 1999.
Madrenas J. Triggering of the T cell receptor: implications ofr transplantation. American Society of Transplantation Winter Symposium. El Conquistador Resort, Las Croabas, Puerto Rico. January 13-17, 2000.
Madrenas J. The balance between versatility and specificity in signal specificity from the T cell receptor for antigen. Canadian Society of Nephrology, Research Symposium, Montreal, Mar. 3, 2000.
Madrenas J. Mechanism of action of engineered antibodies against human CD3. Protein Design Labs M291 Meeting, University of California at San Francisco, San Francisco, Mar. 7, 2000.
Madrenas J. Versatility and specificity of T cell receptor-mediated signal transduction. Institut de Genetique Moleculaire, Montpellier, cedex 5, France. Apr. 4, 2000.
Madrenas J. How does CTLA-4 inhibit T cell activation? Truths and red herrings. Harvard Institutes of Medicine, Boston, MA. June 23, 2000.
Madrenas J. The biological implications of the early signals from the antigen receptor on T lymphocytes. McMaster University Nephrology Grand Rounds, Hamilton, ON. August 18, 2000.
Madrenas J. Negative regulation of T cell activation: lessons from CTLA-4. Centre de Recherche du CHUL, Sainte-Foy, Québec, February 7, 2001.
Madrenas J. Multi-level Regulation of T Cell Receptor-Mediated Signalling. Department of Microbiology and Immunology, the University of Western Ontario, London, ON, March 7, 2001.
Madrenas J. The Complex Regulation of T Cell Activation by CTLA-4. Genetics Institute Inc., Cambridge, MA, March 13, 2001.
Madrenas J. Novel Issues On The Regulation Of Antigen Receptor-Mediated Signalling. March 29, 2001. The John P. Robarts Research Institute Neurodegeneration Group. London, ON.
Madrenas J. What do Matches, Coke and Cell Signaling have in Common? The Science behind Transplantation Medicine. A Scientific Journey: 2001. The University of Western Ontario, London, ON, May 26, 2001.
Madrenas J. Differential T cell Signalling: Implications for Transplantation Tolerance. American Society of Nephrology/International Society of Nephrology World Congress of Nephrology. San Francisco, CA. Oct. 13-17, 2001.
Madrenas J. All I (needed to) know in Biology, I learned from CTLA-4. The John P. Robarts Research Institute Seminar Series, London, ON, November 22, 2001.
Madrenas J. The Art of Immunology. Hadassah – WIZO Organization of Canada – London Hadassah – WIZO. November 25, 2001.
Madrenas J. Signalling Molecules on T cells. Symposium on Novel Advances in Targeted Cellular Therapy in Hematologic Malignancies. American Society of Hematology Corporate Friday Symposium, Orlando FA, Dec. 7, 2001.
Madrenas J. Mechanisms of T cell Inactivation by CTLA-4. American Transplant Congress, Washington D.C., April 26 to May 1, 2002.
Madrenas J. Nueva Actividad Coestimuladora asociada a la Fosfodiesterasa 4B2 en linfocitos T. Centro de Investigaciones Biologicas, Madrid, Spain, May 7, 2002.
Madrenas J. What does Immunology have to do with Sex? The Immunobiology of Sexual Behavior. Robarts Research Institute Board of Directors Meeting, June 5, 2002.
Madrenas J. What does Immunology have to do with Sex? The Immunobiology of Sexual Behavior. Elderhostel Seminar Program, June 12, 2002.
Madrenas J. Xenotransplantation: an update. Ontario Community Nephrology Meeting. Rocky Crest Resort, Mactier, ON, July 12-14, 2002.
Madrenas J. The Art and Science of Grantsmanship: A personal perspective. Nephrology Young Investigators Group, Toronto, ON, August 23-24, 2002.
Madrenas J. The Art of Transplantation Medicine. London Public Library Medical Research Digest Seminar Series, London, ON, September 26, 2002.
Madrenas J. Sex and Immunology. The University of Western Ontario Alumni Association Board of Directors, London, ON, October 4, 2002.
Madrenas J. The therapeutic potential of CTLA-4: A Tale of Three Lysines. Queen’s University, Kingston, ON, October 16, 2002.
Madrenas J. Sex and Immunology. Thames Valley Board of Education High School Science Teachers Professional Development Day, London, ON, October 25, 2002.
Madrenas J. Sex and Immunology. The John P. Robarts Research Institute Council, London, ON, November 7, 2002.
Madrenas J. The Art of Transplantation Medicine. London Dental Study Club, London, ON, November 13, 2002.
Madrenas J. Formation of Immunological Synapses Regulates T cell Activation. Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, January 30, 2003.
Madrenas J. The Other Side of Lck: Negative Regulation of T Cell Activation. Department of Immunology, University of Toronto, April 28, 2003.
Madrenas J. Negative Regulation of T cell Activation. The University of Chicago, Chicago IL, May 27, 2003.
Madrenas J. Mechanism of T cell Down-regulation by CTLA-4. American Diabetes Association 63rd Scientific Sessions. New Orleans, LA, June 13-17, 2003.
Madrenas J. Single molecule nanobiology and Imaging. Robarts Seminar Series. February 12, 2004
Madrenas J. Regulatory role of receptor oligomerization and signalling compartmentalization in T cell activation. Charles Gould Easton Seminar Series, Department of Immunology, University of Toronto, February 23, 2004.
Madrenas J. Modulation of CTLA-4 Function with Recombinant Antibody Fragments. Compound Therapeutics, Waltham, MA, May 3, 2004.
Madrenas J. New Tools for Transplantation. Public Library Lecture Series, London, ON, May 5, 2004.
Madrenas J. Molecular Links between Innate and Adaptive Immunity. Alberta Transplant Institute Nephrology Research Rounds, University of Alberta, Edmonton, May 6, 2004.
Madrenas J. What’s new in T cell activation and costimulation? 14th Annual Alberta Nephrology Days. Edmonton, AB, May 9, 2004.
Madrenas J. Regulation of T cell activation by PDE4B2: a dynamic interplay. Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases. Il Ciocco, Italy, May 30-June 4, 2004.
Madrenas J. Health Research in Canada: CIHR Opportunities. The Canadian Collaboration on Clinical Practice Guidelines in Dentistry (CCCD). Ottawa ON, September 30, 2004.
Madrenas J. Regulation of T cell activation by CTLA-4: how ordered architecture links to signal plasticity. University of Iowa Interdisciplinary Graduate Program in Immunology, Iowa City, IA, December 1, 2004.
Madrenas J. Plasticity of Signal Transduction through CTLA-4. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, February 9, 2005.
Madrenas J. Plasticity of Signal Transduction through CTLA-4. Department of Microbiology and Immunology, The University of Western Ontario, London, ON, February 17, 2005.
Madrenas J. Getting research grants: Not just science, but not only art either. Genzyme Canadian Transplant Fellows Workshop. Banff, AB, March 17, 2005.
Madrenas J. Exploiting signal plasticity of CTLA-4 for therapeutic purposes. CIHR/Transplant Program Seminar Series, Toronto General Hospital, University of Toronto, March 25, 2005.
Madrenas J. Plasticity of CTLA-4 signaling: from structure to therapeutics. University of Sherbrooke Immunology Group Seminar Program, Sherbrooke PQ, April 7, 2005.
Madrenas J. Regulation of T cell activation by CTLA-4: how ordered architecture links to signal plasticity. University of Manitoba Departmen t of Immunology, Winnipeg MB, April 14, 2005.
Madrenas J. The operating grant: a rite of passage for young investigators. CIHR Infection and Immunity Young Investigators Forum, Kingsbridge Conference Centre, April 15-17, 2005.
Madrenas J. Inflammation and Immunity in the peritoneum of Long-Term Peritoneal Dialysis Patients. 1st Annual Meeting of the International Society of Peritoneal Dialysis North American Chapter, Chicago IL, April 30, 2005.
Madrenas J. In the beginning…..there was inflammation. Sanofi-Aventis Biotech Challenge London region. The University of Western Ontario, London, ON, May 5, 2005.
Madrenas J. Happy Birthday, Immunology! The Terrence Donnelly Keynote Lecture. The Canadian Medical Hall of Fame Discovery Days in Health Sciences. May 13, 2005, London, ON.
Madrenas J. Plasticity of signaling through the regulatory receptor CTLA-4. University of Pennsylvania Transplantation Immunobiology Seminar Program, Philadelphia PA, May 18, 2005.
Madrenas J. T-cell activation pathways. American Society of Transplantation Basic Immunology Course, Seattle WA, May 21, 2005.
Madrenas J. Signalling plasticity of transmembrane receptors: from structural biology to immunotherapeutics. Keynote speaker at the 12e Journee de la Recherche de l’Hopital Maisonneuve-Rosemont. Universite de Montreal, June 3, 2005.
Madrenas J. The immunobiology of sexual behaviour. Robarts Redtail Golf Tournament. June 29, 2005.Emerging themes in Immune Cell Activation. Kidney Clinical Research Unit Renal Research Day, The London Health Sciences Centre, London, ON August 18, 2005
Madrenas J. In vivo immune cell activation in the course of peritoneal dialysis and PD-associated peritonities. EuroPD Annual Meeting, Prague, Czek Republic, October 17, 2005
Madrenas J. In vivo immune cell activation in the course of peritoneal dialysis and PD-associated peritonitis. EuroPD Annual Meeting, Prague, Czek Republic, October 17, 2005.
Madrenas J. State of the art lecture on Activation of T cells, Foro: La inmunidad innata y la inmunidad adquirida: 30 Aniversario de Inmunologia Clinica, Association for the Advancement of Science of Venezuela (AsoVAC), Caracas, Venezuela, November 22, 2005.
Madrenas J. The future of Biomedical Research: a personal vision and an institutional vision. Conferencia “Tres enfoques de la Biomedicina Contemporanea”, Association for the Advancement of Science of Venezuela (AsoVAC), Caracas, Venezuela, November 23, 2005
Madrenas J. Stomatin-like protein 2: a key regulator of sustained T cell receptor signalling. Immunity and Infection Research Centre Seminar Series, Vancouver Coastal Health Research institute, January 18, 2006.
Madrenas J. John Hunter and the Mechanistic Framework of Inflammation. Society for Learning in Retirement, London ON, January 27, 2006.
Madrenas J. It’s all about Inflammation. Café Scientifique for the London Community. Masonville Public Library, London ON February 1, 2006.
Madrenas J. How is receptor signaling sustained? On the anchoring machinery of T cell receptor signalosomes. Lerner Research Institute, Cleveland Clinic Foundation. Cleveland, OH. February 22, 2006.
Madrenas J. How is T cell receptor signaling sustained?. Infection, Immunity and Inflammation Seminar Series, Cardiff University, Cardiff, UK. March 9, 2006.
Madrenas J. Inflammation, Research Institutes, and the funding of research in London, Infection and Immunity Seminar Series, London ON, March 16, 2006.
Madrenas J. This ache, that ache…it’s all inflammation. A medical history review. Probus Club of Strathroy and Area. April 11, 2006.
Madrenas J. The art of Transplantation. Kidney Foundation of Canada Southwestern Ontario Chapter. London ON, April 20, 2006.
Madrenas J. This ache, that ache…it’s all about inflammation. Aventis Sanofi Biotech Challenge, London ON May 3, 2006.
Madrenas J. Inflammation, Research Institutes And The Funding Of Science: A History Case Study. 56th Annual Meeting of the Canadian Society of Microbiologists / 49th Annual Meeting of the Genetics Society of Canada. London, ON.
Madrenas J. Emerging themes in T cell activation. 2006 World Transplant Congress. Boston MA, July 22, 2006.
Madrenas J. What does Immunology have to do with the Thyroid? Public Education Meeting, London Central Public Library, London, ON, September 19, 2006.
Madrenas J. Molecular mechanisms of T cell activation during alloresponses. 7th Annual Canadian Transplant Forum. Ottawa ON, November 3, 2006.
Madrenas J. The art of Immunology: how we are protected from microbes. Lucan Central School. Lucan ON, November 14, 2006.
Madrenas J. Signal transduction: from the lab to the clinic. Institut de Investigacions Biomediques Augusti Pi I Sunyer, Barcelona, Spain. November 20, 2006.
Madrenas J. La resposta immunologica als superantigens bacterians: implicacions terapeutiques. Societat Catalana d’Immunologia, Academia de Ciencies Mediques de Catalanuya i Balears, Barcelona, Spain. November 20, 2006.
Madrenas J. Infectious music: how microbes shaped our music. Infection and Immunity Seminar Series, London ON, January 11, 2007.
Madrenas J. Infectious music: how microbes shaped our music. London Life Lunch Seminar Series, London ON, February 6, 2007.
Madrenas J. The bacterial cell wall modulates the immune response to superantigens: Not friendly but Not lethal either. Robarts Research Institute Research Day. London, ON, February 7, 2007.
Madrenas J. Peritoneal dendritic cells. 27th Annual Dialysis Conference, Denver CO, February 17-20, 2007.
Madrenas J. Molecular biomarkers of PD-associated peritonitis. 27th Annual Dialysis Conference, Denver CO, February 17-20, 2007.
Madrenas J. Infectious music: how microbes shaped our music. Lakehead University’s Science and Engineering Symposium (LUSES). Thunder Bay, ON, April 2, 2007.
Madrenas J. Grantmanship. 2nd New Investigator Forum for the CIHR Institute of Infection and Immunity, Kingbridge Centre, King City ON, , April 14, 2007
Madrenas J. The Art of Transplantation. Kidney Foundation of Canada – British Columbia Branch Annual Awards Gala. Richmond, BC, May 5, 2007.
Madrenas J. Stomatin-Like Protein 2 Sustains Signalling from TCR Signalosomes. 4th International Leukocyte Signal Transduction Workshop: Clinical implications of signalling pathways. Rhodes, Greece, June 3-8, 2007.
Madrenas J. Infectious music: how microbes shaped our music. 36th Annual Conference of the Canadian Science Writers’ Association, London ON, June 16, 2007.
Madrenas J. Beyond the Omics, back to biology of T cells. The Alberta Transplant Applied Genomics Centre “Using the “Omic” technologies to phenotype disease: a satellite symposium of the 9th Banff Conference on Allograft Pathology”. Edmonton AB, June 18, 2007.
Madrenas J. T Cell Responses To Bacterial Superantigens: Biological And Therapeutic Implications La Jolla Institute of Allergy and Immunology, La Jolla CA, June 20, 2007.
Madrenas J. Stomatin-like protein 2 (SLP-2): bridging the TCR signalosome with mitochondria. Department of Biochemistry Seminar Series, University of Western Ontario, London ON, September 7, 2007
Madrenas J. Stomatin-like protein 2 (SLP-2): bridging the TCR signalosome with mitochondria. Department of Biochemistry, Microbiology and Immunology Seminar Series, University of Ottawa, Ottawa ON, September 18, 2007.
Madrenas J. Infectious music: how microbes shaped our music. Schulich School of Medicine & Dentistry Mini-Medical School, London ON, October 4, 2007.
Madrenas J. Protein, T cells, and Mitochondria. Department of Microbiology and Immunology Seminar Series, McGill University, Montreal QC, October 12, 2007.
Madrenas J. Infectious Music: how microbes shaped our music. Department of Microbiology and Immunology Graduate Student Seminar, McGill University, Montreal QC, October 12, 2007.
Madrenas J. Stomatin-like protein 2 bridges polarized mitochondria to signalosomes at the immunological synapse. Department of Immunology Special Seminar, University of Toronto, Toronto ON, October 31, 2007.
Madrenas J. Estabilitzacio I sosteniment de la senyalitzacio a traves del TCR. Annual Meeting of the Societat Catalana d’Immunologia, Barcelona, Spain, November 22, 2007.
Madrenas J. Stomatin-like protein 2 (SLP-2): bridging the TCR signalosome with mitochondria. Laboratory of Immunogenetics Seminar Series, NIAID, NIH, Rockville, MD, January 15, 2008.
J. Madrenas. Regulation Of T Cell Activation: Opportunities From Human Experimental Models. Department of Biochemistry, Microbiology and Immunology Seminar Series, University of Ottawa, Ottawa ON, February 21, 2008.
Madrenas J. Infectious music: how microbes shaped our music. 28th Annual Dialysis Conference, Orlando FA, March 3, 2008.
Madrenas J. Stomatin-like protein 2 (SLP-2): bridging the TCR signalosome with mitochondria. Moffitt Cancer Centre Seminar Series, Tampa FA, March 19, 2008.
Madrenas J. Regulation of T cell activation by stomatin-like protein 2: emerging paradigms. Seminar Series of the Department of Cell Biology, University of Geneva, Geneva, Switzerland, April 7, 2008.
Madrenas J. Redescobrint la mitocondria en el context immunologic. Institut de Recerca, Hospital Universitari Vall d’Hebron, Barcelona, Spain, April 9, 2008.
Madrenas J. Stomatin-like protein 2 modulates T cell activation by regulating mitochondrial bioenergetics. Cold Spring Harbour Laboratory Meeting on Gene Expressing and Signalling in the Immune System. Cold Spring Harbour NY, April 22-26, 2008.
Madrenas J. Lymphocytes and dendritic cells: key controllers and effectors. In Symposium on cellular contributors of peritoneal pathology. 12th Congress of the International Society for Peritoneal Dialysis, Istanbul June 20-24, 2008.
Madrenas J. T cell activation and mitochondrial biogenesis. Immunology Seminar Series, Child & Family research Institute, University of British Columbia, Vancouver, BC, September 16, 2008.
Madrenas J: Mechanism of action of CTLA-4: lessons from Ipilimumab. Bristol-Myers-Squibb, Lawrenceville, NJ, October 9, 2008.
Madrenas J. Infectious music: how microbes shaped our music. Canadian Undergraduate Conference on Healthcare, Queen’s University, November 16, 2008.
Madrenas J. The art of grantmanship: Strategies for funding, grant application, common pitfalls. KRESCENT Workshop Meeting, Montreal PQ, November 28, 2008.
Madrenas J. On Mitochondrial Biogenesis During T Cell Activation. Immunology Council Seminar Series, The Johns Hopkins School of Medicine, Baltimore MD, December 2, 2008.
Madrenas J. Superantigens Meet Superbugs: Immunomodulation Of Superantigen-Induced T Cell Responses By The Staphylococcal Cell Wall. Molecular Pathology Seminar Series, The Johns Hopkins School of Medicine, Baltimore MD, December 3, 2008.
Madrenas J. John Hunter and the Discovery of Erythrocyte Sedimentation Rate. Department of History of Medicine, The Johns Hopkins University, Baltimore MD, December 4, 2008.
Madrenas J. Inflamacio o Infeccio: aquesta es la question (terapeutica)!. Department of Physiology, Faculty of Pharmacy, University of Barcelona, December 14, 2008.
Madrenas J. Infectious music. UWO Women in Science and The Department of Mathematics (WISDOM) Seminar Series, London ON. February 5, 2009.
Madrenas J. Infectious music: how microbes shaped our music. Department of Medicine Grand Rounds, The University of Mississippi Medical Center, Jackson MS, February 17, 2009.
Madrenas J. Superantigens Meet Superbugs: modulation of immune responses by the cell wall of S. aureus. Division of Nephrology Seminar Series, The University of Mississippi Medical Center, Jackson MS, February 17, 2009.
Madrenas J. Infectious music: how microbes shaped our music. Annual Dialysis Conference, Houston TX, March 7, 2009.
Madrenas J. Superantigens Meet Superbugs: modulation of T cell activation by the staphylococcal cell wall. Annual Dialysis Conference, Houston TX, March 9, 2009.
Madrenas J. On superantigens and superbugs: modulation of immunity by the cell wall of S. aureus. Department of Molecular Genetics, University of Toronto, March 31, 2009.
Madrenas J. Infectious music: how microbes shaped our music. London Dental Club, April 1, 2009.
Madrenas J. The art of Transplantation. Kidney Foundation of Canada Southwestern Ontario Branch Annual Meeting, London, ON, April 8, 2009.
Madrenas J. On superantigens and superbugs: modulation of immunity by the cell wall of S. aureus. 2e. Rencontre Scientifique du Groupe D’intérêt en Immunologie Du CHUM, Hopital Notre-Dame, Montreal PQ, April 24, 2009.
Madrenas J. T cell activation, differentiation and function. Essential Immunology for the Clinician Symposium. 2009 American Transplant Congress, Boston MA, May 30, 2009.
Madrenas J. On superantigens and superbugs: modulation of immunity by the staphylococcal cell wall. Human Immunology Research Day, University of Toronto, June 10, 2009.
Madrenas J. Immune response to peritonitis: basic mechanisms and clinical implications. 3rd North-American Chapter meeting of the International Society of Peritoneal Dialysis. Vancouver BC, Aug 27-29, 2009.
Madrenas J. Requiem: The Art and Science of Death and Dying. 2009 Mini Medical School Program, Schulich School of Medicine & Dentistry, London ON, October 8, 2009.
Madrenas J. Open Access Publishing in Biological and Medical Sciences. Open Access Week at The University of Western Ontario, London ON October 20, 2009.
Madrenas J. Infectious music: how microbes shaped our music. 2012 Medical Class, The University of Western Ontario, London ON October 21, 2009.
Madrenas J. La mitocondria como regulador de la activacion de los linfocitos T. Symposium on the 30th Anniversary of the Instituto de Inmunologia, Universidad Central de Venzuela, Caracas, Venezuela Oct 27-29, 2009.
Madrenas J. Supermicrobios, superantigenos e inmunidad: evolucion hacia una existencia pacifica. Symposium on the 30th Anniverssary of the Instituto de Inmunologia, Universidad Central de Venezuela, Caracas, Venezuela Oct 27-29, 2009.
Madrenas J. Modulation of human immune responses by ginseng extracts. 2nd Annual Conference of the Ontario Ginseng Innovation & Research Consortium, London ON, November 6-7, 2009.
Madrenas J. Requiem: The art and science of death and dying. Canadian Undergraduate Conference on Healthcare, Queen’s University, November 14, 2009.
Madrenas J. Infectious music: how microbes shaped our music. The Harvey Club of London, London ON November 18, 2009.
Madrenas J. Systems Immunology of S. aureus infection: a novel approach to generate anti-microbials. LHSC – UWO Department of Medicine Clinical Pharmacology Grand Rounds, London ON, November 25, 2009.
Madrenas J. Requiem: the art and science of death and dying. UWO Senior Alumni Seminar Series. London, Ontario, January 5, 2010.
Madrenas J. Requiem: on the art and science of death and dying. Infection and Immunity Seminar Series. London, Ontario, January 28, 2010.
Madrenas J. Slipin Beauty: SLP-2 and its role in mitochondrial biogenesis and cell function. Institute for Genetics, University of Cologne, Cologne, Germany, February 22, 2010.
Madrenas J. Requiem: on the art and science of death and dying. WISDOM Seminar Series, The University of Western Ontario. London, Ontario, February 25, 2010.
Madrenas J. Towards Consilience: an evolutionary view of academic scholarship. Department of Microbiology and Immunology, McGill University, March 23, 2010.
Madrenas J. Requiem: on the art and science of death and dying. London Memorial Society. London, Ontario, April 14, 2010.
Madrenas J. Cultural selection by CIHR: a few evolutionary predictions. CIHR Institute of Infection and Immunity Advisory Board Science Day. Quebec City PQ, May 5-6, 2010.
Madrenas J. Infectious music: how microbes shaped our music. UWO Department of Medicine Friday Rounds, London ON May 21, 2010.
Madrenas J. Bacterial commensalism, inflammation and infection: a Darwinian perspective. Canadian Society of Nephrology Annual Meeting. Montreal PQ, May 29, 2010.
Madrenas J. Immunomodulation by Ginseng extracts. OGIRC 2010 Summer Retreat, London ON, June 15, 2010.
Madrenas J, Singh B. The University of Western Ontario FOCIS Centre of Excellence. FCE Directors Meeting, Annual FOCIS Meeting, Bosotn, MA, June 23, 2010.
Madrenas J. Modulation of innate and adaptive immune responses by ginseng extracts. 10th International Symposium on Ginseng, Seoul, Korea, September 13-16, 2010.
Madrenas J. The Art of Transplantation Medicine. The Kidney Foundation of Canada Sarnia Lambton Chapter 25th Anniversary Celebration, Point Edward ON, September 26, 2010.
Madrenas J. Infectious Music: How Microbes Have Shaped our Music. Inter-Hospital laboratory Continuing Education Program, Exeter ON, September 29, 2010.
Madrenas J. The (Re-)Emergence of Human Immunology: a Philosophical Perspective. 2010 ISHPSSB Off-Year Workshop on Integrating Complexity: Environment and History. London ON, October 7-10, 2010.
Madrenas J. Infectious Music: How Microbes Have Shaped our Music. The Music and Medicine Interest Group, UWO, London ON, December 1, 2010.
Madrenas J. Reclaiming the University: an evolutionary view of academic scholarship. King’s Speakers Series. King’s University College at The University of Western Ontario. London ON, February 14, 2011.
Madrenas J. The art and science of grant grant writing. CST/AST Distinsguished Fellows Research Symposium. 2011 Annual Scientific Meeting of the Canadian Society of Transplantation. Mont-Tremblant PQ, March 2, 2011.
Madrenas J. Funding transplantation research in Canada. Panel discussion. 2011 Annual Scientific Meeting of the Canadian Society of Transplantation. Mont-Tremblant PQ, March 4, 2011.
Madrenas J. Regulation of Adaptive Immune Responses by Innate Immunity: learning from superbugs. 2011 Annual Scientific Meeting of the Canadian Society of Transplantation. Mont-Tremblant PQ, March 5, 2011.
Madrenas J. University: a challenge to embrace change. Seminar Series, Department of Biochemistry, The University of Western Ontario, London ON, March 11, 2011.
Madrenas J. Systems Immunology of S. aureus commensalism and infection. University of Pennsylvania Immunology Colloquium. Philadelphia, PA, March 14, 2011.
Madrenas J. Immunology 101: how the immune system interacts with bacteria. Danoners Training Conference. London ON, April 7, 2011.
Madrenas J. Peritonitis and Immune Response. 2011 World Congress of Nephrology. Vancouver BC, April 11, 2011.

2007-12 The role of SLP-2 in TCR signalosome assembly and T cell activation P.I.
2007-12 London Regional Cell and In Vitro Molecular Imaging Facility Co-P.I.
2007-14 Tier I Canada Research Chair in Immunobiology P.I.
2008-11 New Technologies for Ginseng Agriculture and Product Development Co-P.I.
2010-15 Systems Immunology of S. aureus infection P.I.
2010-12 Modulation of PD-associated peritonitis by the bacterial cell wall P.I.
2011 Rotors and cells for ultracentrifuge Co-P.I.

Courses Taught

1996-00 Immunology
1996-00 Immunology
1996-97 Advanced Immunology
1996-present 4th year project
1995-99 Advanced Microbiology & Immunology
1995-present Departmental Graduate Student Seminar
1996-97 Topics in Advanced Immunology
1996-01 Dental Microbiology and Immunology
2000-01 Drug development, Basic Pharmacology
2001-02 Microbiology and Immunology- coordinator
2001-02 Microbiology and Immunology- coordinator
2002-03 Microbiology and Immunology- coordinator
2002-03 Microbiology and Immunology- coordinator
2003-04 Microbiology and Immunology- coordinator
2003-04 Microbiology and Immunology- coordinator
2003-04 Immunology Journal Club
2004-05 Microbiology and Immunology- coordinator
2004-05 Immunology Journal Club coordinator
2004-05 Microbiology and Immunology- coordinator
2004-05 Immunology Journal Club
2005-06 Microbiology and Immunology- coordinator
2005-06 Microbiology and Immunology- coordinator
2005-06 Scholar’s Elective
2006-07 Immunology Journal Club coordinator
2006-07 Scholar’s Elective
2006-07 Microbiology and Immunology- coordinator
2006-07 Microbiology and Immunology- coordinator
2006-07 Biology of Infection and Immunity
2007-08 Immunology Journal Club coordinator
2007-08 Scholar’s Elective
2007-08 Infection and Immunity coordinator
2007-08 Biology of Infection and Immunity
2008-09 Grant Writing
2008-09 Infection and Immunity coordinator
2008-09 Immunology
2008-09 Immunology Journal Club coordinator
2008-09 Scholars’ elective
2008-09 Biology of Infection and Immunity
2008-09 Creativity – Graduate Course
2009-10 Grant Writing
2009-10 Immunology Journal Club coordinator
2009-10 Immunology
2009-10 Biology of Infection and Immunity
2009-10 Infection and Immunity coordinator
2010-11 Immunology Journal Club coordinator
2010-11 Infection and Immunity coordinator
2010-11 Canadian Studies
2010-11 Graduate Course in Journalism

Clinical Rotation and Specialty Program Teaching:

1995-96 RRI Immunology students and Fellows Data Club
2000-present Nephrology Research Night
2002 Nephrology Fellows – Immunology Session
2004-present Nephrology Residents and Fellows – Immunology
2010 Rheumatology Residents and Fellows – Immunology